Meteorin‐like protein/METRNL/Interleukin‐41 ameliorates atopic dermatitis‐like inflammation

• DOI: 10.1111/all.16150
• Publication Date: 2024-05-10T14:20:15Z
• Authors: Danqi Huang; Xiuting Liu; Xun Gao; Chun Kit Choi; Giovanni Giglio; Luay Farah; Ting‐Fan Leung; Katie Ching‐Yau Wong; Lea Ling‐Yu Kan; Jeffrey Wing‐Heun...; Qing‐Jun Meng; Jinyue Liao; Phyllis Fung‐Yi C...; Chun‐Kwok Wong
• Keywords: atopic dermatitis; skin inflammation; Medizin; Meteorin-like protein (METRNL); WNT signaling pathways; cytokines; ORIGINAL ARTICLE

Meteorin-like protein (METRNL)/Interleukin-41 (IL-41) is a novel immune-secreted cytokine/myokine involved in several inflammatory diseases. However, how METRNL exerts its regulatory properties on skin inflammation remains elusive. This study aims to elucidate the functionality and mechanism of atopic dermatitis (AD). levels were determined serum samples from patients with AD subsequently verified vitamin D3 analogue MC903-induced AD-like mice model. The cellular target activity was identified by multiplex immunostaining, single-cell RNA-seq RNA-seq. significantly upregulated lesions compared healthy controls (p <.05). Following repeated MC903 exposure, model displayed elevated both ears serum. Administration recombinant murine (rmMETRNL) ameliorated allergic hallmarks mice, whereas blocking signaling led opposite. enhanced β-Catenin activation, limited expression Th2-related molecules that attract accumulation Arginase-1 (Arg1)hi macrophages, dendritic cells, activated mast cells. can bind KIT receptor alleviate inhibiting expansion immune downregulating gene regulating level active WNT pathway molecule β-Catenin.