Network analysis reveals age‐ and virus‐specific circuits in nasal epithelial cells of extremely premature infants

• DOI: 10.1111/all.16196
• Publication Date: 2024-06-20T06:05:35Z
• Authors: Lukas Wisgrill; Anke Martens; Rajmund Kasbauer; Michael Eigenschink; Linda Pummer; Monika Redlberger...; Ákos Végvári; Benedikt Warth; Angelika Berger; Nanna Fyhrquist; Harri Alenius
• Keywords: 301902 Immunologie; respiratory infections; 104023 Umweltchemie; nasal epithelial cells; 104023 Environmental chemistry; premature infants; systems biology; 106052 Zellbiologie; 106052 Cell biology; General medicine, internal medicine and other clinical medicine; 301902 Immunology; antiviral immunity

Abstract Background and objectives Viral respiratory infections significantly affect young children, particularly extremely premature infants, resulting in high hospitalization rates increased health‐care burdens. Nasal epithelial cells, the primary defense against infections, are vital for understanding nasal immune responses serve as a promising target uncovering underlying molecular cellular mechanisms. Methods Using trans‐well pseudostratified cell system, we examined age‐dependent developmental differences antiviral to influenza A syncytial virus through systems biology approaches. Results Our studies revealed innate‐receptor repertoires, distinct pathways, differentially connected network circuits between neonatal adult cells. Consensus analysis identified unique shared cellular‐viral networks, emphasizing highly relevant virus‐specific independent of viral replication kinetics. Conclusion This research highlights importance cells innate offers crucial insights that allow deeper age‐related immunity following infections.