Molecular signalling of a novel curcumin derivative versus Tadalafil in erectile dysfunction

• DOI: 10.1111/and.12309
• Publication Date: 2014-07-25T05:08:47Z
• Authors: M. T. Abdel Aziz; A. M. Rezq; H. M. Atta; H. Fouad; A. M. Zaahkouk; H. H. Ahmed; D. Sabry; H. M. Yehia
• Keywords: Male; Curcumin; NF-E2-Related Factor 2; 05 social sciences; NF-kappa B; Phosphodiesterase 5 Inhibitors; p38 Mitogen-Activated Protein Kinases; Diabetes Mellitus, Experimental; Rats; Tadalafil; 3. Good health; Erectile Dysfunction; Animals; 0501 psychology and cognitive sciences; Nitric Oxide Synthase; Cyclic GMP; Heme Oxygenase-1; Penis

The efficacy of a novel curcumin derivative (NCD) versus tadalafil in erectile signalling was assessed. Ten control male rats and 50 diabetic were used divided into the following: (DM), (CURC), NCD, NCD combined with rat groups. Cavernous tissue gene expression heme oxygenase-1 (HO-1), Nrf2, NF-B p38, enzyme activities oxygenase (HO) nitric oxide synthase (NOS), cGMP intracavernosal pressure (ICP)/mean arterial (MAP) Results showed that 12 weeks after induction diabetes, dysfunction (ED) confirmed by significant decrease ICP/MAP, cGMP, NOS, HO activities, HO-1 increase NF-Ҡβ, p38 genes. Administration all therapeutic interventions led to levels, NOS enzymes, HO-1, Nrf2 expression, expression. or its combination superiority more prolonged duration action. In conclusion, tendency observed CURC have high action enhancing function.