Protective antioxidant effects of N -acetylcysteine against impairment of spermatogenesis caused by paranonylphenol

• DOI: 10.1111/and.13114
• Publication Date: 2018-08-03T13:25:41Z
• Authors: Mahdi Malmir; Malek Soleimani M...; Samira Naderi Nor...; Tayebe Faraji
• Keywords: Malondialdehyde; Testicular atrophy

Paranonylphenol (p-NP) is an environmental pollutant that causes oxidative stress. The purpose of this study was to evaluate the protective effect N-acetylcysteine (NAC) as antioxidant on sperm parameters and testis in mice after treatment with p-NP. Adult were randomly divided into four groups (n = 6, each group) including 1-control, 2- p-NP (250 mg kg-1 day-1 ), 3- NAC (150 ) 4- + NAC. After 35 days oral treatment, mean spermatogenic index (p < 0.02), count 0.01), daily production tail length progressive movement 0.04), normal morphology 0.04) viability 0.01) spermatozoa also serum testosterone level significantly reduced group when compared other groups. While positive TUNEL cells seminiferous tubules malondialdehyde (MDA) 0.02) increased. In histopathologic assay group, apoptosis, atrophy, oedema, reduction density lumens vacuoles observed. findings indicate a potent be able compensate adverse effects spermatogenesis, levels MDA group.