Testicular spermatozoon is superior to ejaculated spermatozoon for intracytoplasmic sperm injection to achieve pregnancy in infertile males with high sperm DNA damage

• DOI: 10.1111/and.13175
• Publication Date: 2018-11-26T08:19:47Z
• Authors: Jiyue Zhang; Huiying Xue; Fenglong Qiu; Jixiang Zhong; Jing Su
• Keywords: Spermatozoon; Testicular sperm extraction

The purpose of this study was to compare the clinical outcome testicular spermatozoon versus ejaculated in treatment infertile males with high sperm DNA damage, referred as fragmentation index (DFI), that attending intracytoplasmic injection (ICSI) programme terms pregnancy, births delivered primary and pregnancy loss embryo fertilisation secondary outcome. A total 102 fulfilling inclusion criteria were enrolled present study. Of males, 61 underwent combined ICSI while remaining 41 applied spermatozoa their first cycles, data them collected analysed. In a 18-month follow-up, achieved higher rate deliver than those group (pregnancy rate, 36% vs. 14.6%, p = 0.017; 38.5% 9.8%, 0.001). Nevertheless, there no significant differences number oocytes aspirated embryos transferred between two groups. Additionally, cohort (70.4%) also similar (75.0%). Based on current data, we conclude is prior option DFI programme. More high-quality studies larger samples size are needed future due relative small nonrandomized design