Intratunical injection of human urine‐derived stem cells derived exosomes prevents fibrosis and improves erectile function in a rat model of Peyronie's disease

• DOI: 10.1111/and.13831
• Publication Date: 2020-09-28T18:28:29Z
• Authors: Qiyun Yang; Wanmei Chen; Dayu Han; Chi Zhang; Yun Xie; Xiangzhou Sun; Guihua Liu; Chunhua Deng
• Keywords: Myofibroblast; Transdifferentiation; Tunica albuginea (penis); Hydroxyproline

We aimed to evaluate the effects of intratunical injection exosomes derived from human urine-derived stem cells (USC-exo) on plaque formation and erectile function in a transforming growth factor-β1 (TGF-β1) induced Peyronie's disease (PD) rat model. Twenty-four SD rats were randomly assigned equally three groups: (I) Sham group (50 μl phosphate-buffered saline [PBS] injected into tunica albuginea [TA]), (II) PD (0.5 μg TGF-β1 50 PBS TA) (III) USC-exo ug plus 100 TA at same day). The maximum intracavernous pressure (ICPmax) mean arterial (MAP) each evaluated 4 weeks after injection. formation, fibrosis, matrix metalloproteinases (MMPs) tissue inhibitor MMPs (TIMPs) evaluated. Four injection, showed more significantly enhanced ICPmax ICPmax/MAP than (p < .05). could ameliorate fibrosis that be associated with inhibition transdifferentiation fibroblasts myofibroblasts, decreased expression TIMPs (TIMP-1, 2, 3) increased activity (MMP-1, 3, 9) TA. According these findings, can new candidate for prevention PD.