Association of heat shock protein A2 expression and sperm quality after N‐acetyl‐cysteine supplementation in astheno‐terato‐zoospermic infertile men

• DOI: 10.1111/and.14024
• Publication Date: 2021-03-04T15:44:43Z
• Authors: Rahil Jannatifar; Ebrahim Cheraghi; Mohammad Hossein ...; Hamid Piroozmanesh
• Keywords: Semen Analysis; Semen quality

In infertile men, reduced expression of heat shock protein A2 (HSPA2) is related to sperm quality and function. The present study has aimed investigate the effects N-acetyl-cysteine (NAC) supplementation on (HSPA2). this in continuation previous study, semen samples from 50 astheno-terato-zoospermic men who have received NAC (600 mg/day) orally for three months were evaluated HSPA2 using RT-PCR, Western blot analysis. addition, these individuals assessed parameters, DNA fragmentation (TUNEL), protamine deficiency (CMA3), lipid peroxidation index (MDA) total antioxidant capacity (TCA). All assessment was carried out before after treatment. addition improved parameters aforementioned functional presented results revealed significant increase relative levels obtained treatment (p < .05). Correlation analysis also demonstrated that significantly most parameters. may directly or indecently impose its beneficial effect through increased HSPA2, which plays a potential role proper folding element needed counteract stress condition individuals.