Successful outcomes of intracytoplasmic sperm injection–embryo transfer using ejaculated spermatozoa from two Chinese asthenoteratozoospermic brothers with a compound heterozygous FSIP2 mutation

• DOI: 10.1111/and.14351
• Publication Date: 2021-12-22T04:28:24Z
• Authors: Yuan Yuan; Wen‐qing Xu; Zi‐yi Chen; Ying Chen; Li Zhang; Liping Zheng; Tao Luo; Hou‐yang Chen
• Keywords: Proband; Compound heterozygosity; Asthenozoospermia

Multiple morphological abnormalities of the sperm flagella (MMAF) is a characteristic form severe asthenozoospermia and closely related to male infertility. However, it not sure whether intracytoplasmic injection (ICSI) allows MMAF patients reproductive success. The present study reported first case successful injection-embryo transfer (ICSI-ET) in Chinese brothers with novel compound heterozygous mutation FSIP2 (fibrous sheath interacting protein 2), newly identified MMAF-related genes. proband his brother were referred for because their abnormal flagellum. Through whole-exome sequencing genetic analyses proband, parents showed that carry (c.1750T>A c.13600A>G), which will lead expression loss its function. Considering these had phenotype, we recommended ICSI treatment. outcome indicated lose-function might have any effect on ICSI, although latest report failed patient mutation. This provides new knowledge understand caused by outcome.