The rs5934505 single nucleotide polymorphism (SNP) is associated with low testosterone and late‐onset hypogonadism, but the rs10822184 SNP is associated with overweight and obesity in a Chinese Han population: a case–control study

• DOI: 10.1111/andr.12127
• Publication Date: 2015-11-25T06:23:03Z
• Authors: Y.‐p. Chen; L.‐L. Nie; H.‐g. Li; T.‐h. Liu; F. Fang; K. Zhao; R.‐f. Yang; X.‐l. Ma; X.‐b. Kong; H.‐p. Zhang; H.‐t. Guan; W. Xia; W.‐x. Hong; S. Duan; X.‐c. Zeng; X.‐j. Shang; Y.‐z. Zhou; Y.‐q. Gu; W.‐x. Wu; C.‐l. Xiong
• Keywords: SNP

Summary Low testosterone is associated with late‐onset hypogonadism ( LOH ) and obesity. Recently, studies have shown that four single nucleotide polymorphisms SNP s), rs12150660, rs727428, rs5934505, rs10822184, are levels in populations of European descent. Therefore, we investigated whether the loci related to low testosterone, , or obesity a Chinese Han population. Ruling out co‐morbidities, DNA was prepared from 409 men (aged 40–65 years) serum (defined as total <11.6 nmol/L) 1 : normal controls (matched age, body mass index BMI ), same living area) who were selected 6898 males. According standards, 310 Excluding cases an unreliable sequencing result, genetic analyses performed. The minor allele frequencies rs10822184 0.1%, 44.6%, 18.7%, 38.9%, respectively. rs5934505 calculated free (CFT) p = 0.045 0.021). (C>T) increased risk CFT, adjusted for other factors, odds ratio OR 2.01 (1.34–3.01), 2.14 (1.42–3.20), 1.64 (1.04–2.58). significantly correlated weight 0.035 0.027). (T>C) overweight We ratios s) 1.94 (1.36–2.78) 1.56 (1.00–2.43). In summary, our study provided convincing evidence populations. first find However, further large functional warranted confirm findings.