Glucagon‐like peptide‐1 receptor is expressed in human and rodent testis

• DOI: 10.1111/andr.12871
• Publication Date: 2020-07-24T16:06:17Z
• Authors: Rosario Caltabiano; Daniele Condorelli; Salvatore Panza; Carla Boitani; Nicolò Musso; Davor Ježek; Lorenzo Memeo; Lorenzo Colarossi; Vittoria Rago; Valentina Mularoni; Saveria Spadola; Roberto Castiglione; Marta Santoro; Saveria Aquila; Rosario D'Agata
• Keywords: Incretin

Abstract Background The incretin hormone glucagon‐like peptide‐l (GLP‐1) is an important regulator of post‐prandial insulin secretion, acting through a G protein‐coupled cell surface receptor (GLP‐1R). In addition to its expression in pancreatic β‐cells, several studies suggested that GLP‐1R located extra‐pancreatic tissues. Objectives this study, we examined for the first time testicular distribution GLP‐1R, both normal human and neoplastic tissues as well rodent testis lines. Methods section has been evaluated by immunohistochemistry, specificity IHC was validated demonstrating positive staining GLP‐1RmRNA RISH technology. While terms protein detected western blot analysis, Moreover, mRNA levels were determined testis, Leydig, Sertoli Results Using immunohistochemistrya specific Leydig cells. only these types. Species differences between humans rodents observed. Interestingly, decreased tumor line absence samples detected. Discussion It may be hypothesized acts like oncosuppressor tumors. A role regulation secretion GLP‐1 shown other endocrine cells, therefore able modulate somehow function. Conclusion our findings, careful evaluation revealed cells potential target GLP‐1. Collectively, effect function presumed although future are needed ascertain GLP‐1R’s