No detection of SARS‐CoV‐2 from urine, expressed prostatic secretions, and semen in 74 recovered COVID‐19 male patients: A perspective and urogenital evaluation

• DOI: 10.1111/andr.12939
• Publication Date: 2020-11-05T08:00:15Z
• Authors: Yajun Ruan; Bintao Hu; Zhuo Liu; Kang Liu; Hongyang Jiang; Hao Li; Rui Li; Yang Luan; Xiaming Liu; Gan Yu; Shengfei Xu; Xiaoyi Yuan; Shaogang Wang; Weimin Yang; Zhangqun Ye; Jihong Liu; Tao Wang
• Keywords: Sex organ

The coronavirus disease 2019 (COVID-19) has been spreading all over the world since December 2019. However, medical information regarding urogenital involvement in recovered COVID-19 patients is limited or unknown.To comprehensively evaluate patients.Men aged between 20 years and 50 who were diagnosed with SARS-CoV-2 infection when study was conducted enrolled our study. Demographic clinical characteristics, history of hospitalization collected analyzed. Urine, expressed prostatic secretions (EPSs), semen samples for RNA detection. Semen quality hormonal profiles analyzed.Among 74 male patients, 11 (14.9%) asymptomatic, classified into mild type, 31 (41.9%) moderate type. remaining (32/74, 43.2%) had severe pneumonia. No critically ill patient recruited cohort. median interval last positive pharyngeal swab RT-PCR test collection 80 days (IQR, 64-93). age 27-36; range, 21-49), body mass index (BMI) 24.40 22.55-27.30). Forty-five (61.6%) men married, 28 (38.4%) unmarried. Fifty-three (72.6%) denied cigarette smoking, 18 (24.7%) active smokers, 2 them past smokers. majority participants (53/74, 72.6%) did not consume alcohol. Fever occurred most (75.3%), 63 abnormal chest CT images. Only one complained scrotal discomfort during course COVID-19, which ruled out orchitis by MRI (data shown). A total 205 detection (74 urine samples, 70 61 EPS samples). viral nucleic acid detected fluids from system. In terms profiles, levels FSH, LH, testosterone, estradiol 5.20 [4.23] mIU/mL, 3.95 [1.63] 3.65 [1.19] ng/mL, 39.48 [12.51] pg/mL, respectively. And these values within normal limits. overall above lower reference limit released WHO. While compared healthy control, sperm concentration, count, motility significantly declined. addition, different types have no significant difference parameters, but count showed a descending trend. Interestingly, subjects longer recovery time worse data quality. Small sample size lacking parameters before are major limitations study.To best knowledge, it largest cohort longest follow-up evaluation so far. Direct found patients. undetectable secretions, declined slightly, while remained normal. Moreover, long (≥90 days) count. Great attention further should be on reproductive function following months.