Cortisol modulates Ca2+ signaling and acrosome reaction in human sperm

• DOI: 10.1111/andr.13319
• Publication Date: 2022-10-17T16:39:19Z
• Authors: Sheini Ruturi Sán...; Esperanza Mata Ma...; Jorge Arturo Torr...; Rodolfo José Arias; Gerardo Andrés De...; Ana Alicia Sánche...
• Keywords: Acrosome reaction

Abstract Background Stress and elevated cortisol levels have negative effects on fertility, although there is controversy about the effect of human sperm. One study reported that hydrocortisone (HC), synthetic form cortisol, does not activate CatSper channel but able to inhibit its activation by progesterone (Pg). However, subsequent reports showed HC has an agonist CatSper, producing intracellular Ca 2+ ([Ca ] i ) increases. These studies were performed using only electrophysiological techniques fluorometric measurements . Therefore, it important evaluate different concentrations sperm physiology other approaches techniques. Objective To analyze association perceived stress, anxiety depression with acrosome reaction (AR), semen quality. Materials methods In capacitated sperm, we tested [Ca mobilization AR. Furthermore, stress symptoms evaluated standardized psychometric tests. Results induces a low increase in compared Pg response while, at higher concentrations, inhibits Pg‐induced response. Also, induce AR when co‐incubating Pg, percentages are decreased. Finally, negatively correlated induced Discussion our data also suggest may compete for binding site Pg. Additionally, between decreased could be explained high levels. Conclusion Our interferes action. correlation due accompanying this condition competitive action