Restless legs syndrome in Wilson's disease: frequency, characteristics, and mimics

• DOI: 10.1111/ane.12585
• Publication Date: 2016-03-05T16:56:52Z
• Authors: M. C. Trindade; T. Bittencourt; G. Lorenzi-Filho; R. C. Alves; D. C. de Andrade; E. T. Fonoff; E. Bor-Seng-Shu; A. A. Machado; M. J. Teixeira; E. R. Barbosa; G. G. Tribl
• Keywords: Restless Legs Syndrome; Neurological examination

To determine characteristics, clinical significance, frequency, and mimics of restless legs syndrome (RLS) in a cohort Wilson's disease (WD, n = 42/f 18), compared to healthy, matched controls.Structured interviews (patients caregiving family members), repeated neurological examinations (afternoon presleep), comprehensive laboratory tests, WD-, RLS-, sleep-specific rating scales, video-polysomnography.Thirteen patients with WD (13/42 31.0%) clearly fulfilled the five diagnostic criteria RLS; eight (19.1%), burden RLS was clinically significant. The moderate severity, equally distributed among sexes, manifested mainly evening before falling asleep, had developed mostly after manifestation (time elapsed 10.2 ± 14.5 years), still at young mean age (27.5 11.5 years). known RLS-associated features were absent (normal iron kidney parameters) or rare (positive history, polyneuropathy). Compared without RLS, significantly elder suffered longer from WD. WD-specific as well confounding motor comorbidities (dystonia, tremor, chorea) frequent challenge; difficult cases, differentiation reached by observation behavior nighttime.RLS this might be causally related should included work-up In complex disorders, differential diagnosis require evening/nighttime examination video-polysomnography. significant treatment dopaminergic substances may considered.