Patterns of dopamine transporter imaging in subtypes of multiple system atrophy

• DOI: 10.1111/ane.12932
• Publication Date: 2018-03-24T23:56:33Z
• Authors: L.-L. Bu; F.-T. Liu; C.-F. Jiang; S.-S. Guo; H. Yu; C.-T. Zuo; P. Wu; J. Wang
• Keywords: Putamen; Pathophysiology

To investigate the differences in pattern of striatal (caudate and putamen) dopamine transporter (DAT) loss a multiple system atrophy (MSA) cohort, based on clinical variants parkinsonian subtype (MSA-P) cerebellar (MSA-C) via (11)C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane (11 C-CFT) positron emission tomography (PET) imaging.One hundred six subjects (forty-one patients with probable MSA-P; forty MSA-C; twenty-five healthy controls) underwent 11 C-CFT PET. Subregional uptake bilateral caudate, anterior putamen, posterior putamen was calculated respectively to measure dopaminergic function.Significant decrease DAT binding striatum revealed MSA-C MSA-P compared normal controls (all regions, vs controls, P < .0001; .0001). reduction more pronounced than that Eleven displayed no loss, whereas evident all patients. showed obvious anteroposterior gradient asymmetric dysfunction patients.The subtypes MSA studied here show significantly different spatial/anatomic patterns striatonigral degeneration which may provide insights into their disease pathophysiology. Specifically, exhibit an uneven much greater innervation, while relatively uniform is MSA-C. Furthermore, typical not present patients, minority cases showing binding.