Neuropsychological tests are useful for predicting comorbidities of idiopathic normal pressure hydrocephalus

• DOI: 10.1111/ane.13306
• Publication Date: 2020-07-03T21:01:34Z
• Authors: Chihiro Kamohara; Madoka Nakajima; Kaito Kawamura; Chihiro Akiba; Ikuko Ogino; Hanbing Xu; Kostadin Karagiozov; Hajime Arai; Masakazu Miyajima
• Keywords: Stroop effect; Trail Making Test

Objectives Comorbidities of idiopathic normal pressure hydrocephalus (iNPH), such as Alzheimer's disease (AD) and Parkinson's spectrum (PS) disorder, can affect the long-term prognosis cerebrospinal fluid (CSF) shunting. Therefore, it is important to be able predict comorbidities in early stage disease. This study aimed iNPH using neuropsychological tests cognitive performance evaluation. Materials & Methods Forty-nine patients with possible were divided into three groups: without AD or PS comorbidity (group-1), (group-2), (group-3), according CSF biomarkers phosphorylated tau dopamine transporter imaging. Scores on new EU-iNPH-scale, which based 4 (Rey Auditory Verbal Learning Test, Grooved Pegboard test, Stroop colour-naming test interference test), compared for each group. In addition, scores before 12 months after shunting group compared. Results EU-iNPH-scale could distinguish group-1 from group-2 group-3 by area under curve values 0.787 0.851, respectively. Patients showed a remarkable increase memory learning ability surgery. Group-2 performed significantly poorer than testing, but otherwise improvements most tests. Group-3 worse patients—especially tests—but post-surgery improvement only test. Conclusions The help evaluate