Persistent olfactory dysfunction after COVID‐19 is associated with reduced perfusion in the frontal lobe

• DOI: 10.1111/ane.13627
• Publication Date: 2022-04-25T10:33:33Z
• Authors: Miguel Yus; Jordi A. Matias‐Guiu; Lidia Gil‐Martínez; Natividad Gómez‐Ruiz; Carmen Polidura; Manuela Jorquera; Cristina Delgado‐...; María Díez‐Cirarda; Jorge Matías‐Guiu; Juan Arrazola
• Keywords: Pathophysiology; Frontal lobe

Olfactory dysfunction is common during SARS-CoV-2 infection. The pathophysiology of the persistence this symptom and potential relationship with central nervous system involvement unknown.To evaluate neural correlates persistent olfactory in a series patients post-COVID syndrome.Eighty-two syndrome were assessed Brief Smell Identification Test multimodal MRI study including 3D-T1, T2-FLAIR, diffusion-tensor imaging, arterial spin labeling. neuroimaging examinations performed 11.18 ± 3.78 months after acute Voxel-based brain mapping analyses conducted to correlate test volumes, white matter microstructure, perfusion.Olfactory was associated lower tissue perfusion orbital medial frontal regions labeling sequence. Conversely, no statistically significant findings detected volumes imaging. Mild changes paranasal sinuses nasal cavities 9.75% cases, association deficits.We provide new insights regarding COVID-19, involving main system.