Prognostic value of positron emission tomography/computed tomography for adjuvant chemotherapy of colon cancer

• DOI: 10.1111/ans.14098
• Publication Date: 2017-07-07T23:56:43Z
• Authors: HyungJoo Baik; Seok Mo Lee; Sang Hyuk Seo; Min Sung An; Kwang Hee Kim; Ki Beom Bae; Min Kyung Oh; Kwan Hee Hong
• Keywords: Standardized uptake value; FOLFOX; Univariate analysis; Fluorodeoxyglucose

To assess the prognostic value of preoperative 18 F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with high-risk stage II or III colon cancer who underwent FOLFOX chemotherapy.The study included 166 received FOLFOX4 chemotherapy. Retrospective patient data were analysed including pathological stage, histology, disease-free survival (DFS) and maximum standardized uptake (SUVmax ) primary tumour on tomography. The end point was DFS.There recurrences 29 (17.4%). Measuring area under receiver operating characteristic curve, cut-off SUVmax sensitivity specificity 10.95. Using Kaplan-Meier method, DFS categorized by tended to differ (P = 0.055). In univariate analyses, risk factors for age over 70 years, higher N neural invasion. ≤ 10.95 showed a tendency, but not significant 0.0604). multivariate invasion.The results this suggest that high fluorodeoxyglucose mass does significantly correlate DFS.