Postoperative inflammatory responses and association with in‐hospital mortality after general surgery

• DOI: 10.1111/ans.70115
• Publication Date: 2025-04-04T20:03:33Z
• Authors: Joshua G. Kovoor; Stephen Bacchi; Kayla Nathin; Nidhi Aujayeb; Amy Lu; Neel C. Mishra; Daksh Tyagi; Brandon Stretton; Aashray K. Gupta; Thomas J. Hugh; Guy J. Maddern
• Keywords: Absolute neutrophil count; Demographics

The relationship between postoperative in-hospital mortality and inflammatory markers has not been well described. This study aimed to characterize the association specific clinical of inflammation in early period general surgical patients. included consecutive surgery admissions at two tertiary hospitals South Australia over a 2-year period. Collected data patient demographics, Charlson comorbidity index, mortality, vital signs, laboratory tests. In particular, temperature, neutrophil count, lymphocyte platelet albumin level, C-reactive protein (CRP) were collected for 48 h after surgery. Multivariable logistic regression was conducted examine first 24 postoperatively 24-48 postoperatively. 5493 patients included, with an average age 52.8 (SD 19.4). 2548 (46.4%) female, 53 (1.0%) experienced mortality. postoperatively, temperature >38°C, count >14 × 109/L, >5 109/L significantly associated increased likelihood whereas platelets, albumin, CRP during not. Between increases maximum counts, counts changes is response using markers, their relative 2 days