Enlarged posterior fossa on prenatal imaging: differential diagnosis, associated anomalies and postnatal outcome

• DOI: 10.1111/aogs.13131
• Publication Date: 2017-03-14T21:33:11Z
• Authors: Anja Wüest; Daniel Surbek; Roland Wiest; Christian Weissta...; Harald Bonel; Maja Steinlin; Luigi Raio; Boris Tutschek
• Keywords: Cerebellar hypoplasia (non-human); Posterior cranial fossa; Agenesis

The primary aim of this study was to ascertain the prevalence individual conditions and associated anomalies in fetuses with prenatal diagnosis enlarged posterior fossa (PF) explore diagnostic accuracy ultrasound these anomalies. secondary evaluate postnatal outcome children affected by PF anomalies.All detected sonography at a referral center from 2001 2015 were analyzed retrospectively. Some also studied fetal magnetic resonance imaging (MRI) or volume examinations. Fetal sonographic MRI compared using following classification: Dandy-Walker malformation (DWM); megacisterna magna (MCM); Blake's pouch cyst; isolated vermian hypoplasia; agenesis; arachnoid cyst (AC); cerebellar hypoplasia (CH).The diagnoses 69 as follows: MCM (n = 29; n 15), DWM 28, 4), 5, 4, 1), CH 2; none isolated) AC 1, isolated). Thirteen 41 karyotyped aneuploid, including seven DWM. Associated malformations found 37/69 cases. There 39 live births, 11 confirmed DWM, six whom show normal development. Twelve infants eight false-positive (or resolution until birth) "enlarged PF": three cyst, two one hypoplasia.An requires specific for best possible counseling. term "Dandy-Walker variant" should not be used anymore. Isolated can either resolve variants, but may indicate presence more severe anomaly malformations.