Plasma long‐chain omega‐3 fatty acid status and risk of recurrent early spontaneous preterm birth: a prospective observational study

• DOI: 10.1111/aogs.14147
• Publication Date: 2021-03-20T08:15:51Z
• Authors: Laura Goodfellow; Angharad Care; Jane Harrold; Andrew Sharp; Jelena Ivandic; Borna Poljak; Devender Roberts; Ana Alfirevic; Bertram Müller‐My...; Robert Gibson; Maria Makrides; Zarko Alfirevic
• Keywords: Adult; eicosapentaenoic acid; 610; Preterm birth; Prenatal Care; docosahexaenoic acid; 300; United Kingdom; long-chain polyunsaturated fatty acids; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Risk Factors; Dietary Supplements; Fatty Acids, Omega-3; Humans; Premature Birth; Female; Prospective Studies; omega-3

Abstract Introduction A 2018 Cochrane review found that omega‐3 supplementation in pregnancy was associated with a risk reduction of early preterm birth 0.58; prompting calls for universal supplementation. Recent analysis suggests the benefit may be confined to women low baseline fatty acid status. However, contemporary status pregnant UK is largely unknown. This particularly pertinent previous birth, whom small relative would have larger absolute risk. study aimed assess population and determine association between long‐chain acids recurrent spontaneous birth. Material methods total 283 high‐risk were recruited prospective observational Liverpool, UK. Additionally, 96 term births ≥39 +0 weeks index provided low‐risk sample. Within group we assessed odds ratio compared at ≥37 gestation according plasma eicosapentaenoic plus docosahexaenoic (EPA+DHA) 15–22 gestation. Results Our participants had EPA+DHA; 62% (143/229) 69% (68/96) sample levels within lowest two quintiles previously published cohort. We no ( n = 51). The crude event 0.91 (95% CI 0.38–2.15, p 0.83) lowest, highest three EPA+DHA. Conclusions In majority our participants, low; range from showed could because too show being “replete”; or else lesser importance