Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow‐up six months after birth

• DOI: 10.1111/aogs.14582
• Publication Date: 2023-06-04T05:18:03Z
• Authors: Karina Hjort‐Pede...; Annette Wind Olesen; Ester Garne; Lene Sperling
• Keywords: Danish; Congenital malformations

To investigate the performance of second-trimester ultrasound scan regarding ultrasound-detectable congenital malformations in a Danish region. The study sample was population-based, with 6 months postnatal follow-up. Hospital records and autopsy reports were reviewed each case to validate prenatal diagnosis.This population-based cohort included all fetuses (n = 19.367) alive at four hospitals final diagnosis based on hospital during 6-month In termination or stillbirth, result from report used diagnosis.The detection rate screening program 69%, where 18% detected first-trimester 51% scan. Another 8% third trimester. Specificity 99.9%. positive predictive value 94.5%, negative 99.5%. overall prevalence 16.8 per 1000 fetuses, most frequently heart urinary tract.This shows that national for can detect many severe is an effective test malformations.