Bone Marrow Stem Cells‐Seeded Polyethylene Terephthalate Scaffold in Repair and Regeneration of Rabbit Achilles Tendon

• DOI: 10.1111/aor.13298
• Publication Date: 2018-10-08T05:49:49Z
• Authors: Jiangyu Cai; Yimeng Yang; Chengchong Ai; Wenhe Jin; Dandan Sheng; Jun Chen; Shiyi Chen
• Keywords: Rabbit (cipher)

Abstract The objective of this study was to evaluate the effect bone marrow stem cells (BMSCs)‐seeded polyethylene terephthalate (PET) scaffold for Achilles tendon repair in a rabbit model. allogeneic BMSCs were seeded onto PET and cultured vitro 14 days. Sixteen mature New Zealand rabbits underwent surgery establish 2‐cm defect BMSCs‐seeded implanted into one limb (BMSCs‐PET group), while without contralateral as control (PET group). All sacrificed at 6 12 weeks after surgery. At surgery, macroscopic histological results showed formation tendon‐like tissues, structure more BMSCs‐PET group. Immunohistochemical analysis real‐time polymerase chain reaction (RT‐PCR) demonstrated that collagen I III significantly higher group compared with those Mechanically, both failure load average stiffness than In conclusion, could effectively facilitate healing process being