Dissemination of a novel organ perfusion technique: ex vivo normothermic perfusion of deceased donor kidneys

• DOI: 10.1111/aor.13499
• Publication Date: 2019-05-14T16:07:25Z
• Authors: Pankaj Chandak; Benedict L. Phillips; Raphael Uwechue; Emily Thompson; Lucy Bates; Ibrahim Ibrahim; Avinash Sewpaul; Rodrigo Figueiredo; Jonathon Olsburgh; Sarah Hosgood; Michael L. Nicholson; Colin Wilson; Chris J. Callaghan
• Keywords: Ex vivo

Abstract Ex vivo normothermic perfusion (EVNP) technology is a promising means of organ preservation, assessment, and preconditioning prior to kidney transplantation, which has been pioneered by single group. We describe the challenges setting up clinical EVNP programs in 2 new centers, as well early patient outcomes. Governance, training, logistical pathways are described. In order demonstrate safety proficiency this technique, outcomes also Patient included incidence primary nonfunction, delayed graft function, survival at 1 year. Contralateral kidneys undergoing static cold storage alone were used comparator Between March 2016 July 2017, was performed on 14 from 12 donors (11 center 1, 3 2). Of that underwent EVNP, organs implanted into 10 recipients. Two pairs dual grafts simultaneously with pancreas. The remaining 7 transplanted allografts. Seven available for paired analysis comparing versus storage. Graft comparable between preservation techniques. introduction service requires careful multimodal approach, drawing expertise specialists hematology, microbiology. Both demonstrated when structured dissemination process followed.