Impact of extracorporeal blood pump gap sizes on the performance and hemocompatibility under off‐design operation

• DOI: 10.1111/aor.14875
• Publication Date: 2024-09-26T10:43:19Z
• Authors: Lars Fischer; Sebastian V. Jansen; Ulrich Steinseifer; Ifan Yen; Po‐Lin Hsu; Michael Neidlin
• Keywords: Design of experiments

Abstract Background Hemocompatibility remains the dominant challenge in rotary blood pumps, and more information on relationship between individual pump design features, hemodynamics, trauma various operation conditions is necessary. The study evaluated variation of gap sizes extracorporeal pumps concerning their influence compatibility, particularly during off‐design conditions. Methods We developed a parametric generic framework for in‐silico in‐vitro feature analysis. Thirty‐six designs with varying axial radial 0.5 mm 3 were generated. CFD was applied to calculate compare device hemodynamics evaluate performance hemocompatibility target following quantities analyzed: pressure difference, hemolysis potential, residence times, hydraulic efficiency, recirculation ratio. Results prototype showed excellent agreement predictions regarding ( R 2 = 0.996 RMSE 2.07). Our results show modest impact size variations ±10% key metrics. Domain‐resolved analyses revealed significant contribution regions device's overall hemolytic performance, an increasing flow rates. Overall elevated levels identified if at least one held minimal. Conclusions introduced feasibility systematically investigate impact. suggest, larger uniformly sized gaps being beneficial hemocompatibility.