Circulating cell‐free DNA in liver transplantation: A pre‐ and post‐transplant biomarker of graft dysfunction

• DOI: 10.1111/aor.14910
• Publication Date: 2024-11-18T12:44:24Z
• Authors: Monica Sorbini; Tullia Carradori; Damiano Patrono; Gabriele Togliatto; Cristiana Caorsi; Tiziana Vaisitti; Morteza Mansouri; Luisa Delsedime; Elena Vissio; Nicola De Stefano; Mauro Papotti; Antonio Amoroso; Renato Romagnoli; Silvia Deaglio
• Keywords: Cell-free fetal DNA

Liver transplantation (LT) is still limited by organ shortage and post-transplant monitoring issues. While machine perfusion techniques allow for improving preservation, biomarkers like donor-derived cell-free DNA (dd-cfDNA) mitochondrial cfDNA (mt-cfDNA) may provide insights into graft injury viability pre- post-LT.