Investigating M101's Effect in Improving Cardiac and Diaphragmatic Mechanical and Functional Properties on Wistar Rat

• DOI: 10.1111/aor.15014
• Publication Date: 2025-05-06T10:44:46Z
• Authors: Ollivier Grimault; Michael Theron; Quentin Boete; Mathieu Maalouf; Jean‐Baptiste Qué...; Franck Zal; Karelle Léon; Karine Pichavant‐...
• Keywords: Diaphragm (acoustics); Cardiac muscle

ABSTRACT Background The critical importance of effective oxygen delivery during organ preservation to prevent ischemia–reperfusion injury has been reported in the literature. Moreover, traditional methods often fail meet oxygenation needs, prompting research into alternatives like hemoglobin‐based carriers (HBOCs) such as M101 provided by HEMARINA. This extracellular hemoglobin, derived from Arenicola marina , shows a high affinity for and delivers it through physiological gradient under hypoxic conditions. Methods In this context, mechanical functional properties heart diaphragm muscles Wistar rats were evaluated presence M101. Results experiments showed that M101‐treated hearts maintained higher contraction amplitudes, rates, coronary flow over time compared controls, indicating improved stability. Furthermore, exhibited prolonged relaxation times, with significant improvements amplitude at stimulation frequencies. Finally, Burke index revealed reduced fatigue group controls. Conclusions These findings suggest significantly enhances both tested experimental Further is warranted unravel these explore clinical applications.