Interleukin‐22 serum levels are elevated in active scleritis

• DOI: 10.1111/aos.13005
• Publication Date: 2016-03-24T09:52:05Z
• Authors: Maite Sainz‐de‐la...; Blanca Molins; Marina Mesquida; Victor Llorenç; Javier Zarranz‐Ve...; Anna Sala‐Puigdol...; Jessica Matas; Alfredo Adan; C. Stephen Foster
• Keywords: Adult; Aged, 80 and over; Male; Interleukins; Enzyme-Linked Immunosorbent Assay; Middle Aged; Interleukin-22; 03 medical and health sciences; 0302 clinical medicine; Case-Control Studies; Cytokines; Humans; Female; Prospective Studies; Aged; Scleritis

Abstract Purpose To evaluate serum cytokine profile from patients with active scleritis in a two‐centre prospective case–control study. Methods The of 20 not treated any local, periocular, or systemic immunomodulatory therapy ( IMT ) was analysed multiplex assay to determine the levels 11 cytokines interleukin IL )‐1 β , ‐6, ‐2, IFN ‐ γ ‐10, ‐12p40, ‐13, ‐17A, ‐5, TNF α and ELISA TGF 1, ‐22, ‐23. Twenty‐five age‐matched healthy volunteers were used as controls. In subgroup 13 disease, second sample obtained when disease inactive ‐22 determined. Serum correlated type (non‐necrotizing necrotizing), degree inflammation (0–4+ :≤2+ >2+), associated disease. Results elevated compared controls (6.41 ± 1.52 pg/ ml versus 1.93 0.39 p = 0.012) significantly decreased after remission use (p 0.005). There no statistical association type, inflammation, other different Conclusion our study cohort, remission. Our results suggest that T helper (Th) 17‐ Th22‐ derived cytokine, may play critical role physiopathology scleritis.