Cytomegalovirus and other common enteric viruses are not commonly associated with NEC

• DOI: 10.1111/apa.13110
• Publication Date: 2015-07-04T10:50:50Z
• Authors: Thomas Skeath; Christopher Stewart; Sheila Waugh; Nicholas Embleton; Stephen Cummings; Janet Berrington
• Keywords: Astrovirus; Cytomegalovirus; Sapovirus; Etiology; Enteric virus

Abstract Aim Changes in gut microbiota may contribute to NEC, but most studies focus on bacteria. Case reports suggest a link between cytomegalovirus (CMV) or other enteric viruses and there are few case series systematically looking at common potential viral causes. We aimed assess the presence of candidate blood stool infants with NEC managed one surgical centre. Methods identified 22 diagnosed (from November 2011 March 2014): 17 had suitable stored, whom 14 also samples stored. Blood was analysed polymerase chain reaction (PCR) for CMV, Epstein–Barr virus (EBV) adenovirus, by PCR norovirus, sappovirus, astrovirus, adenovirus rotavirus. Results All were negative. Conclusion Although indicate an episodic association inability detect any these our suggests that aetiology is unlikely be causative sporadic forms NEC.