Multi‐organ dysfunction scoring in neonatal encephalopathy (MODE Score) and neurodevelopmental outcomes

• DOI: 10.1111/apa.16111
• Publication Date: 2021-09-16T07:40:41Z
• Authors: Deirdre Una Sweetman; Tammy Strickland; Eman Isweisi; Lynne Kelly; Marie Therese Slevin; Veronica Donoghue; Judith Meehan; Geraldine Boylan; John Finbar Antho...; Afif El‐Khuffash; Eleanor J. Molloy
• Keywords: Neonatal Encephalopathy; Organ dysfunction; Perinatal asphyxia

Neonatal encephalopathy (NE) is associated with an increased risk of multi-organ injury. The lack standardised definitions for dysfunction in NE hinders accurate quantification these complications.A simple neonatal scoring (MODE) system was created to include the cardiovascular, respiratory, gastrointestinal, haematological and neurological systems a maximum score 15. MODE then compared grade NE, Bayley Scales Infant Development (Bayley-III) at 2 years age mortality. used as it gave objective making easier compare score. <90 and/or abnormal MRI adverse outcome.Infants perinatal asphyxia (PA:n = 85) were prospectively enrolled (PA only n 9; I 23; II 42; III 11). Infants higher scores significantly more likely have moderate/severe (NE II/III: median (IQR) 7(5-10) versus mild (1-3); p-value < 0.001) highly predictive mortality (AUC 0.96, 0.002). who had examination discharge or Bayley-III (p-value 0.001).Quantifying injury important plan optimal early management long-term follow-up. Additional use clinical biomarkers may be useful surrogate endpoints future trials link longer-term developmental