Retracted: Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats

• DOI: 10.1111/apha.13285
• Publication Date: 2019-04-20T12:28:57Z
• Authors: Marta Toral; Iñaki Robles‐Vera; Néstor de la Visi...; Miguel Romero; Manuel Sánchez; Manuel Gómez‐Guzmán; Alba Rodriguez‐No...; Tao Yang; Rosario Jiménez; Francesca Algieri; Julio Gálvez; Mohan K Raizada; Juan Duarte
• Keywords: Endothelial Dysfunction

High blood pressure (BP) is associated with gut microbiota dysbiosis. The aim of this study was to investigate whether changes in induced by exchanging the between spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) alter gut-immune system interaction inducing vascular function BP.Twenty-week-old recipient WKY SHR were orally gavaged donor faecal contents from or SHR. In additional experiments, we used a design determine blockade B7-dependent costimulation CTLA4-Ig IL-17 IL-17-neutralizing antibody could prevent hypertension caused transplantation (FMT) WKY.Correlation analyses identified bacterial abundance Turicibacter S24-7_g that, respectively, positively negatively correlated systolic BP. FMT reduced basal BP, restored imbalance Th17/Treg mesenteric lymph nodes (MLNs) aorta, improved endothelial dysfunction oxidative status found transplanted faeces. increased CD80 CD86 mRNA levels T cells activation MLNs, circulating cells, aortic cell infiltration, impaired SBP. These effects abolished CTLA4-Ig. IL-17a neutralizing SBP WKY.Gut an important factor involved control as consequence its effect T-cell immune T-cells accumulation.