Oxytocin modulates neural processing of mitral/tufted cells in the olfactory bulb

• DOI: 10.1111/apha.13626
• Publication Date: 2021-02-13T08:16:26Z
• Authors: Changcheng Sun; Zhaoyang Yin; Ben‐Zheng Li; Han Du; Keke Tang; Penglai Liu; Sio Hang Pun; Tim C. Lei; Anan Li
• Keywords: Neurons; Mice; 0303 health sciences; 03 medical and health sciences; Odorants; Animals; Humans; Oxytocin; Olfactory Bulb

Abstract Aim Oxytocin plays an important role in social recognition rodents, which is mediated predominantly by the olfactory system. Although oxytocin modulates neural activity bulb, underlying mechanism largely unknown. Here, we studied how direct infusion of into bulb affect interactions mice and modulate mitral/tufted cells bulb. Methods A three‐chamber interaction test was used behavioural test. For vivo studies, single unit recordings, local field potential recordings fibre photometry were to record vitro performed patch clamp slice Results Behaviourally, increased performance a task. Moreover, odour‐evoked responses discrimination odours both enhanced oxytocin, whereas spontaneous firing rate reduced. At network level, decreased amplitude high gamma responses. cell population calcium (reflecting activity) specifically granule cells. revealed that inhibitory effect on mitral mainly modulation ATP‐sensitive potassium channels involves receptor–Gq–PLC–IP 3 signalling pathway. Conclusion interaction, likely increasing signal‐to‐noise ratio odour partly through channel.