Inter‐individual variability in redox and performance responses after antioxidant supplementation: A randomized double blind crossover study

• DOI: 10.1111/apha.14017
• Publication Date: 2023-07-04T06:34:11Z
• Authors: Nikos V. Margarit...; George G. Nastos; Olga Vasileiadou; Panagiotis N. Cha...; Anastasios A. The...; Vassilis Paschalis; Ioannis S. Vrabas; Antonios Kyparos; Ioannis G. Fatouros; Michalis G. Nikol...
• Keywords: Crossover study

Abstract Aim We aimed to investigate the inter‐individual variability in redox and physiological responses of antioxidant‐deficient subjects after antioxidant supplementation. Methods Two hundred individuals were sorted by plasma vitamin C levels. A low group ( n = 22) a control compared terms oxidative stress performance. Subsequently, received for 30 days (1 g) or placebo, randomized, double‐blind, crossover fashion, effects examined through mixed‐effects model, while individual calculated. Results The exhibited lower (−25 μmol/L; 95%CI[−31.7, −18.3]; p < 0.001), higher F 2 ‐isoprostanes (+17.1 pg/mL; 95%CI[6.5, 27.7]; 0.002), impaired VO 2max (−8.2 mL/kg/min; 95%CI[−12.8, −3.6]; 0.001) isometric peak torque (−41.5 Nm; 95%CI[−61.8, −21.2]; group. Regarding supplementation, significant treatment effect was found (+11.6 95%CI[6.8, 17.1], (−13.7 95%CI[−18.9, −8.4], (+5.4 95%CI[2.7, 8.2], (+18.7; 95%CI[11.8, 25.7 Nm], 0.001). standard deviation (SDir) greater than smallest worthwhile change (SWC) all variables indicating meaningful variability. When minimal clinically important difference (MCID) set, remained , but not torque. Conclusion proportion response generally high supplementation (82.9%–95.3%); however, few participants did benefit from treatment. This underlines potential need personalized nutritional interventions an exercise physiology context.