Biomarkers for iron metabolism among patients hospitalized with community‐acquired pneumonia caused by infection with SARS‐CoV‐2, bacteria, and influenza

• DOI: 10.1111/apm.13259
• Publication Date: 2022-06-25T14:29:07Z
• Authors: Maria Hein Hegelund; Andreas Glenthøj; Camilla Koch Ryrsø; Christian Ritz; Arnold Matovu Dungu; Adin Sejdic; Karoline Cecilie ...; Rikke Krogh‐Madsen; Birgitte Lindegaard; Jørgen Anders Lin...; Daniel Faurholt‐J...
• Keywords: 0301 basic medicine; Community-acquired pneumonia; Iron; Pneumonia, Viral; Hepcidin; 03 medical and health sciences; Hepcidins; Influenza, Human; Faculty of Science; Pneumonia, Bacterial; Humans; /dk/atira/pure/core/keywords/TheFacultyOfScience; Ferritin; 0303 health sciences; SARS-CoV-2; COVID-19; Iron metabolism; 3. Good health; Community-Acquired Infections; C-Reactive Protein; Cross-Sectional Studies; /dk/atira/pure/core/keywords/TheFacultyOfScience; name=Faculty of Science; Ferritins; Erythroferrone; Biomarkers

Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators metabolism in context The aim was to evaluate biomarkers for acute phase response community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP bacteria or influenza virus hospitalized patients. A cross-sectional study 164 patients from Surviving Pneumonia Cohort recruited between January 8, 2019 and May 26, 2020. Blood samples were collected at admission analyzed levels C-reactive protein (CRP), ferritin, soluble transferrin receptor, erythroferrone, hepcidin. Median (IQR) hepcidin higher 143.8 (100.7-180.7) ng/mL bacterial infection 78.8 (40.1-125.4) 53.5 (25.2-125.8) ng/mL, respectively. median ferritin level more than 2-fold other etiologies (p < 0.001). Patients had lower erythroferrone CRP those infected bacteria. Higher despite among indicate alterations infection.