Serum I‐FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies

• DOI: 10.1111/apt.12194
• Publication Date: 2013-01-07T12:13:39Z
• Authors: M. P. M. Adriaanse; G. J. Tack; V. Lima Passos; J. G. M. C. Damoi...; M. W. J. Schreurs; K. van Wijck; R. G. Riedl; A. A. M. Masclee; W. A. Buurman; C. J. J. Mulder; A. C. E. Vreugdenhil
• Keywords: Enterocyte; Villous atrophy; Tissue transglutaminase

Enterocyte damage is the hallmark of coeliac disease (CD) resulting in malabsorption. Little known about recovery enterocyte and its clinical consequences. Serum intestinal fatty acid binding protein (I-FABP) a sensitive marker to study damage.To evaluate severity adult-onset CD course upon gluten-free diet (GFD). Furthermore, correlation among damage, autoantibodies histological abnormalities during studied.Serum I-FABP levels were determined 96 biopsy-proven adult patients 69 repeatedly GFD. A total 141 individuals with normal antitissue transglutaminase antibody (IgA-tTG) served as controls. related degree villous atrophy (Marsh grade) IgA-tTG.I-FABP elevated untreated (median 691 pg/mL) compared controls 178 pg/mL, P < 0.001) correlated Marsh grade (r = 0.265, 0.05) IgA-tTG 0.403, 0.01). Upon GFD serum decreased significantly, however, not within range observed controls, despite common normalisation grade. nonresponding showed persistent abnormalities.Enterocyte assessed by correlates at time diagnosis. Although improves treatment, substantial persists absence low majority cases. Elevated are indicative warrant further evaluation.