Endoscopic ultrasound of the colon for the differentiation of Crohn's disease and ulcerative colitis in comparison with healthy controls

• DOI: 10.1111/apt.12671
• Publication Date: 2014-02-26T02:40:35Z
• Authors: M. Ellrichmann; P. Wietzke‐Braun; S. Dhar; S. Nikolaus; A. Arlt; J. Bethge; T. Kuehbacher; L. Wintermeyer; K. Balschun; W. Klapper; S. Schreiber; A. Fritscher‐Ravens
• Keywords: Submucosa; Lamina propria; Histology

Summary Background Diagnosis of inflammatory bowel disease ( IBD ) is based on clinical presentation, colonoscopy and histology. Differentiation Crohn's CD ulcerative colitis UC can be difficult in some patients. Endoscopic ultrasound EUS provides high resolution images the gastrointestinal wall GI may an alternative to differentiate / . Aim layers patients with healthy controls HC for differential diagnosis a prospective, blinded study. Methods Consecutive , or underwent mid sigmoid colon forward‐viewing radial echoendoscope. Mucosal, submucosal, total thickness TWT locoregional lymphnodes LN were assessed by fashion. was correlated macroscopic scores histological inflammation scores. Results Total 61 1.71 ± 0.02 mm, 3.51 0.15 mm n = 52 active In significant thickening mucosa observed but nearly normal submucosa m.propria. submucosal layer seen m.propria [Mucosa 2.08 0.11 Mucosa 1.32 0.17 P 0.0001); Submucosa 1.01 0.08 2.01 0.22 0.0001)]. 73.7% none paracolonic lymph nodes detected. When mucosal‐submucosal s combined, sensitivity 92.3% differentiation There strong correlation : r 0.43; 0.69). Conclusions Increased has positive predictive value from quantify level colonic inflammation.