Survival after treatment with curative intent for hepatocellular carcinoma among patients with vs without non‐alcoholic fatty liver disease

• DOI: 10.1111/apt.14342
• Publication Date: 2017-09-28T16:03:59Z
• Authors: C. R. Wong; B. Njei; M. H. Nguyen; A. Nguyen; J. K. Lim
• Keywords: Decompensation

Non-alcoholic fatty liver disease (NAFLD) is expected to become a leading aetiology of hepatocellular carcinoma (HCC)-related mortality in the United States. HCC treatments with curative intent (OLT, orthotopic transplantation; resection; RFA, radiofrequency ablation) can improve survival carefully selected patients.To compare after receipt treatment for NAFLD and non-NAFLD-HCC aetiologies (HCV, chronic hepatitis C; HBV, B; ALD, alcoholic disease) by was performed.A cohort 17 664 patients assembled using linked Surveillance, Epidemiology, End Results Medicare data from 1991 2011 confirmed diagnosis HCC.The mostly male, aged 70 (21-106) years, without cardiovascular disease, had cirrhosis decompensation, metastatic or large tumour size (>5 cm). The NAFLD-HCC group female older more HCC, less decompensated than groups. 47% likely receive any as compared non-NAFLD (OR 0.53, P < .001). worse median OLT (3.2, 0-12.9 = .01) but improved resection (2.4, 0-12.0 .001) non-NAFLD-HCC. No significant differences existed RFA aetiology. not an independent predictor OLT, RFA.Patients favourable resection, particularly absence cirrhosis, aetiologies.