Intensity of surveillance for hepatocellular carcinoma determines survival in patients at risk in a hepatitis B‐endemic area

• DOI: 10.1111/apt.14623
• Publication Date: 2018-04-03T06:10:22Z
• Authors: H. Y. Kim; J. Y. Nam; J.‐H. Lee; H. A. Lee; Y. Chang; H. Y. Lee; H. Cho; D. H. Lee; Y. Y. Cho; E. J. Cho; S. J. Yu; J. M. Lee; Y. J. Kim; J.‐H. Yoon
• Keywords: Hepatitis B

Data are insufficient regarding the survival benefit of surveillance for hepatocellular carcinoma (HCC).To investigate effectiveness HCC in a hepatitis B-endemic population.This retrospective cohort study included 1402 consecutive patients who were newly diagnosed with between 2005 and 2012 at single tertiary hospital Korea. The primary endpoint was overall survival. Lead-time length-time biases adjusted (sojourn time = 140 days) sensitivity analyses performed.The most common aetiology B (80.4%). Cirrhosis present 78.2%. during regular (defined as mean interval ultrasonography <8 months, n 834), irregular (n 104) or nonsurveillance 464). Patients group earlier stages ([very] early stage, 64.4%) than (40.4%) (26.9%) groups had more chance curative treatments (52.4%) (39.4%) (23.3%) (all P < 0.001). Mortality risk significantly lower (adjusted hazard ratio [aHR], 0.69; 95% [CI], 0.57-0.83) but not (aHR, 0.94; CI, 0.69-1.28) compared after adjusting confounding factors lead-time. When subjects restricted to cirrhotic Child-Pugh class A/B patients, similar results obtained mortality reduction groups.HCC associated longer owing diagnosis treatment. Survival advantage significant surveillance.