Oesophageal secretions reveal local food‐specific antibody responses in eosinophilic oesophagitis

• DOI: 10.1111/apt.17220
• Publication Date: 2022-09-21T02:43:00Z
• Authors: Ashley L. Pyne; Mark W. Hazel; Amiko M. Uchida; Fares Qeadan; Kristine C. Jordan; Amy Holman; Brinnlie Harward; Gerald J. Gleich; Kathryn A. Peterson
• Keywords: Eosinophilic Esophagitis; Immunoglobulin A

Summary Background Eosinophilic oesophagitis (EoE) is associated with elevated IgG4 in oesophageal tissue and serum. Previously, we showed brush‐collected secretions of EoE patients contained food antigen‐specific antibodies IgA IgG4. It unknown whether other food‐specific are present along the surface oesophagus EoE. Aim To identify immunoglobulins than mucosal Methods Concentrations total IgA, IgG1, IgG2, IgG3, IgG4, IgM IgE were measured from active ( n = 19) inactive 9), non‐EoE controls 10). Food‐specific using beads coupled to protein components dairy, wheat egg. Total immunoglobulin cytokine chemokine concentrations serum, saliva four Results Oesophageal have a unique immune profile. Patients had compared those significantly increased patients. Furthermore, known dairy trigger display higher dairy‐specific IgM, IgE. Conclusions There distinct localised profile found within These findings expand our knowledge about currently identified responses suggest possible roles for multiple pathophysiology