Epidemiology and risk factors for histopathologic characteristics of non‐alcoholic fatty liver disease in South America

• DOI: 10.1111/apt.17615
• Publication Date: 2023-06-24T22:51:05Z
• Authors: Joseph A. Akambase; Jhon E. Prieto; Angelo Z. Mattos; Angelo A. Mattos; Enrique Carrera; Javier Díaz‐Ferrer; Patricia Gallardo; Andrea Curia; Esteban G. Ballerga; Cristiane V. Tovo; Domingo Balderramo; Jose D. Debes
• Keywords: Steatosis; Dyslipidemia

Summary Background The burden of non‐alcoholic fatty liver disease (NAFLD) in South America is among the highest world. However, epidemiology and risk factors for NAFLD are insufficiently described region. Aim To explore associations between clinical characteristics histopathological features Methods This was a descriptive study 2722 patients with from 8 medical centres across 5 American countries. We collected clinical, biochemical data using templated chart. Fibrosis assessed by elastography or fibrosis scores confirmed biopsy when available. examined logistic regression models. Models were adjusted country, age sex. Results median 53 years (IQR: 41–62), 63% women. Subjects Brazil had body mass index at 42 kg/m 2 . Sixty‐seven percent dyslipidemia, 46% obesity, 30% hypertension, 17% type diabetes mellitus (T2DM) 34% metabolic syndrome. Biopsy reports available 948 (35%), which 58% showed fibrosis, 91% steatosis 65% inflammation; 25% significant 27% severe steatosis. Metabolic syndrome, T2DM hypertension significantly associated (OR = 1.94, p < 0.001; OR 2.93, 0.001 1.60, 0.003, respectively), 2.05, 1.91, 2.17, 0.001, respectively) inflammation 1.66, 0.007; 2.00, 0.002; 1.62, respectively). Conclusions In largest cohort to date America, independently steatosis, inflammation. prevalence lower than reported global prevalence.