Leucine‐Rich Alpha‐2 Glycoprotein Is Associated With Transmural Inflammation Assessed by Intestinal Ultrasound in Patients With Crohn's Disease

• DOI: 10.1111/apt.18430
• Publication Date: 2024-12-06T10:34:12Z
• Authors: Moeko Komatsu; Shintaro Sagami; Aya Hojo; Ryo Karashima; Masa Maeda; Yoko Yamana; Kanade Serizawa; Satoko Umeda; Kunio Asonuma; Masaru Nakano; Toshifumi Hibi; Takahisa Matsuda; Taku Kobayashi
• Keywords: Rank correlation

ABSTRACT Background Intestinal ultrasound (IUS) is a non‐invasive tool for evaluating transmural inflammation in Crohn's disease (CD). However, its utility constrained by operator dependency and limited accessibility. Aims To explore the feasibility of serum biomarkers—specifically leucine‐rich alpha‐2 glycoprotein (LRG)—as an alternative to IUS assessing inflammation. Methods This retrospective, single‐centre study included patients with CD who underwent measurements LRG C‐reactive protein (CRP). We assessed correlations between biomarkers five scores (Limberg score, Bowel Ultrasound Score (BUSS), International Segmental Activity (IBUS‐SAS), Simple (Simple‐US) Disease (SUS‐CD)) using receiver characteristic curve analysis Spearman's rank correlation coefficient. conducted subgroup analyses clinical remission. Results analysed 213 examinations performed on 97 patients; 170 (80%) were during The area under each score (0.76, 0.80, 0.77, 0.75 0.69, respectively) was superior that CRP statistically significant, particularly LS, BUSS, IBUS‐SAS Simple‐US ( p < 0.001, = 0.018, 0.001 respectively). Predictive values remained consistent among demonstrated excellent both overall patient population those Conclusion showed robust scores, suggesting potential as novel indicator targeting healing CD.