Effects of high ambient temperature on plasma metabolomic profiles in chicks

• DOI: 10.1111/asj.12951
• Publication Date: 2017-11-20T11:58:51Z
• Authors: Shozo Tomonaga; Hirofumi Okuyama; Tetsuya Tachibana; Ryosuke Makino
• Keywords: Niacinamide; 2. Zero hunger; 0301 basic medicine; Hot Temperature; Taurine; Tryptophan; Environmental Exposure; Quinolinic Acid; Gas Chromatography-Mass Spectrometry; Molecular Weight; Amino Acids, Sulfur; Oxidative Stress; 03 medical and health sciences; Cystathionine; Animals; Cystine; Cysteine; Chickens; Homocysteine; Kynurenine

Exposure to high ambient temperature is detrimental the poultry industry. To understand influence from a metabolic perspective, we investigated effects of exposure on plasma low-molecular-weight metabolite levels in chicks using gas chromatography/mass spectrometry-based non-targeted metabolomic analysis. Heat for 4 days suppressed growth and food intake. Of 92 metabolites identified, 29 decreased, whereas nine increased. We performed an enrichment analysis identified found 35 candidates processes affected by heat exposure. Among them, sulfur amino acid pathway was clearly detected following related were decreased: cystathionine, cysteine, cystine, homocysteine hypotaurine. Changes kynurenine tryptophan metabolism, which linked immune system oxidative stress, also observed: quinolinic increased, nicotinamide decreased. These results suggest possible involvement various heat-exposed chicks. Some these would be important mechanism biological responses