Associations of statin use with glycaemic traits and incident type 2 diabetes

• DOI: 10.1111/bcp.13898
• Publication Date: 2019-03-06T05:30:52Z
• Authors: Fariba Ahmadizar; Carolina Ochoa‐Ro...; Marija Glisic; Oscar H. Franco; Taulant Muka; Bruno H. Stricker
• Keywords: Rotterdam Study; Impaired fasting glucose

Aims There are several epidemiological studies on the association between statins and incident diabetes, but most of them lack details. In this study, we aimed to investigate statin use with glycaemic traits type 2 diabetes. Methods Using prospective population‐based Rotterdam Study, included 9535 individuals free from diabetes at baseline (>45 years) during study period 1997 2012. Linear regression analysis was applied examine cross‐sectional associations including fasting blood serum glucose insulin concentrations, resistance. a longitudinal follow‐up Cox determine adjusted hazard ratios (HR) for in new users statins. Results The mean age 64.3 ± 10.1 years 41.7% were men. fully model, compared never statins, associated higher concentrations (β = 0.07; 95% CI: 0.02–0.13) resistance 0.09; 0.03–0.14). Ever 38% risk (HR 1.38; 1.09–1.74). This more prominent subjects impaired homeostasis overweight/obese individuals. Conclusions Individuals using may be hyperglycaemia, eventually Rigorous preventive strategies such as control weight reduction patients when initiating therapy might help minimize