The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis

• DOI: 10.1111/bcpt.12574
• Publication Date: 2016-03-01T14:37:32Z
• Authors: Zsolt Sandor; Andras Dekany; Dezsö Kelemen; Timea Bencsik; Robert Papp; Lorand Bartho
• Keywords: Atropine; 0303 health sciences; Scopolamine; Cholinergic Agents; Receptors, Purinergic; Nerve Tissue Proteins; Tetrodotoxin; In Vitro Techniques; 03 medical and health sciences; Jejunum; Transient Receptor Potential Channels; Isothiocyanates; Purines; Humans; Acetanilides; Calcium Channels; Capsaicin; TRPA1 Cation Channel; Muscle Contraction

AbstractThe contractile effect of AITC (300 μM) on human jejunal longitudinal strips was inhibited by the TRPA1 antagonist HC 030031 and atropine or scopolamine, but was insensitive to tetrodotoxin, purinoceptor antagonists or capsaicin desensitization. It is concluded that TRPA1 activation stimulates a cholinergic mechanism in a tetrodotoxin‐resistant manner.