Apoptotic Process Induced by Oxaliplatin in Rat Hippocampus Causes Memory Impairment

• DOI: 10.1111/bcpt.12629
• Publication Date: 2016-06-06T15:08:49Z
• Authors: Enrica Bianchi; Lorenzo Di Cesare...; Laura Micheli; Mersedez Farzad; Margherita Aglianò; Carla Ghelardini
• Keywords: Memory Impairment

Aspects of memory involved in cognitive mechanisms were investigated rat after oxaliplatin (OX) chemotherapy using animal behavioural assessment passive avoidance and social learning paradigms, which are both hippocampus-sensitive. Rodents, previously subjected to 2-week OX treatment, showed impairment apoptotic processes the hippocampus. Apoptosis rate significantly increased cultured hippocampal cells exposed at increasing doses, this effect was dose-dependent. Ex vivo experiments that cell damage apoptosis blocked hippocampus from rats cotreated with copper sulphate (CS) precludes transport inside cell. In vivo, could not be observed co-administered CS. Thus, a site action treatment on appears located These findings strongly support cellular induced by rodent underlies weakening some functions.