Drugs for hyperlipidaemia may slow down the progression of hearing loss in the elderly: A drug repurposing study

• DOI: 10.1111/bcpt.13150
• Publication Date: 2018-10-16T14:08:10Z
• Authors: Oak‐Sung Choo; Dukyong Yoon; Young Choi; Soojung Jo; Ho‐Min Jung; Jun Young An; Yun‐Hoon Choung
• Keywords: Presbycusis

Hearing loss in the elderly causes communication difficulties, decreased quality of life, isolation, loneliness and frustration. The aim this study was to identify modifiable variables that may affect progression hearing elderly. A case-control conducted using two data sets. Data were extracted from health examination survey Ajou University Hospital (2010-2014) Korea National Health Nutrition Examination Survey (2009-2012) Audiometry evaluated according such as age, sex drug use for underlying diseases. Logistic regression analysis performed on entire population, middle-aged groups odds ratios (ORs). Factors including older female gender diabetes mellitus significantly associated with levels all age (OR [95% confidence interval, 95% CI], 0.375 [0.388-0.415], 1.202 [1.195-1.208], 1.427 [1.183-1.721], respectively). However, when results compared, medication hyperlipidaemia had a positive effect preservation group 0.713 [0.567-0.897]), but not 0.967 [0.791-1.183]). People, especially those group, exposed are likely have better than drugs. Thus, drugs prescribed maintain overcome potential confounding-by unmeasured variables-that is present study, further studies must be more elaborate research design methodology.