Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice

• DOI: 10.1111/bcpt.13498
• Publication Date: 2020-09-25T14:05:43Z
• Authors: Xixi Jia; Liqun Zhang; Wen Zhang; Yang Zhou; Yanan Song; Chang Liu; Ning Yang; Jie Sun; Zhuonan Sun; Zhengqian Li; Chengmei Shi; Yongzheng Han; Yi Yuan; Jie Shi; Yajie Liu; Xiangyang Guo
• Keywords: Luzindole; Sleep

Post-operative sleep disorders induce adverse effects on patients, especially the elderly, which may be associated with surgery and inhalational anaesthetics. Melatonin is a neuroendocrine regulator of sleep-wake cycle. In this study, we analysed alterations post-operative in aged melatonin-deficient (C57BL/6J) mice, investigated if exogenous melatonin could facilitate entrainment circadian rhythm after laparotomy under sevoflurane anaesthesia. The results showed that anaesthesia had greater influence than alone. Laparotomy led to shifting forward, altered EEG power density delta NREM sleep, lengthened REM latencies. light phase, number waking episodes tended decline, wake episode duration elevated. However, these indicators presented opposite tendency during dark phase. significant efficacy for ameliorating disorder restoring physiological most beneficial effect was antagonized by luzindole, receptor antagonist.