Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice
Activity Cycles
Sleep Wake Disorders
Laparotomy
Time Factors
Electromyography
Photoperiod
Age Factors
Sleep, REM
Electroencephalography
Circadian Rhythm
3. Good health
Mice, Inbred C57BL
Sevoflurane
Mice
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Sleep Aids, Pharmaceutical
Anesthetics, Inhalation
Animals
Female
Sleep Stages
Melatonin
DOI:
10.1111/bcpt.13498
Publication Date:
2020-09-25T14:05:43Z
AUTHORS (16)
ABSTRACT
AbstractPost‐operative sleep disorders induce adverse effects on patients, especially the elderly, which may be associated with surgery and inhalational anaesthetics. Melatonin is a neuroendocrine regulator of the sleep‐wake cycle. In this study, we analysed the alterations of post‐operative sleep in aged melatonin‐deficient (C57BL/6J) mice, and investigated if exogenous melatonin could facilitate entrainment of circadian rhythm after laparotomy under sevoflurane anaesthesia. The results showed that laparotomy under sevoflurane anaesthesia had a greater influence on post‐operative sleep than sevoflurane alone. Laparotomy under anaesthesia led to circadian rhythm shifting forward, altered EEG power density and delta power of NREM sleep, and lengthened REM and NREM sleep latencies. In the light phase, the number of waking episodes tended to decline, and wake episode duration elevated. However, these indicators presented the opposite tendency during the dark phase. Melatonin showed significant efficacy for ameliorating the sleep disorder and restoring physiological sleep, and most of the beneficial effect of melatonin was antagonized by luzindole, a melatonin receptor antagonist.
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CITATIONS (7)
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