Prevalence of Patients Admitted to Intensive Care After Administration of Chlordiazepoxide in the Emergency Room

• DOI: 10.1111/bcpt.70018
• Publication Date: 2025-03-12T10:25:45Z
• Authors: Jakob Nørgaard He...; Sara Buttrup Rose...; Dorte Goldbækdal ...; Charlotte Uggerhø...
• Keywords: Chlordiazepoxide

ABSTRACT Chlordiazepoxide is effective in treating alcohol withdrawal syndrome, but it poses a risk of long‐term sedation. The prevalence this side effect and its factors remain uncertain. This retrospective cross‐sectional study aimed to estimate both using data from Aarhus University Hospital's BI portal. We identified manually reviewed patient records 1 September 2019 31 August 2021, including the physicians' conclusions on ICU admissions determine whether they were likely due chlordiazepoxide toxicity. was administered 1363 unique patients period. 32 preceded by administration, 5 which (16%) related Patients with chlordiazepoxide‐induced received higher cumulative doses compared other (425 mg vs. 150 mg, p = 0.01), had longer stays (median 8 2 days, 0.01) required flumazenil ( 0.04). Their median age above 60 years, not all known liver disease. overall incidence toxicity approximately 0.35%, 60. Our findings suggest increased caution when only disease also elderly for symptoms.