Effect of vitamin D supplementation and ultraviolet B exposure on serum 25-hydroxyvitamin D concentrations in healthy volunteers: a randomized, crossover clinical trial

• DOI: 10.1111/bjd.12349
• Publication Date: 2013-04-01T15:04:45Z
• Authors: Z. Lagunova; A.C. Porojnicu; L. Aksnes; M.F. Holick; V. Iani; Ø.S. Bruland; J. Moan
• Keywords: Erythema; Crossover study; sed

Solar ultraviolet (UV) radiation during the summer and vitamin D supplementation are two major sources of for humans at northern latitudes. However, little is known about relative efficiency these sources.The main goal was to compare high-dose oral D3 (2000 IU per day 30 days) with a simulated UV exposure [10 sunbed sessions total dose 23·8 standard erythema doses (SED)] improve status.Healthy volunteers were randomized into groups: group 1 received followed by 10 whole-body exposures; 2 started exposures supplementation.The resulted in mean (SEM) serum 25-hydroxyvitamin [25(OH)D] increase 25·3 (5·4) nmol L(-1) . A similar increase, 19·8 , observed after exposure. At end study, 25(OH)D concentrations both groups.Twice-weekly 4·8 SED equal 2000 daily days enough achieve maintain > 75 ~55% cases. Based on our calculations, this corresponds cumulative weekly 3·4 (~ 40 min around midday latitude Oslo).