Calculation of cut‐off values based on the Autoimmune Bullous Skin Disorder Intensity Score ( ABSIS ) and Pemphigus Disease Area Index ( PDAI ) pemphigus scoring systems for defining moderate, significant and extensive types of pemphigus

• DOI: 10.1111/bjd.14405
• Publication Date: 2016-01-22T14:01:53Z
• Authors: C. Boulard; S. Duvert Lehembre; C. Picard‐Dahan; J.S. Kern; G. Zambruno; C. Feliciani; B. Marinovic; P. Vabres; L. Borradori; C. Prost‐Squarcioni; B. Labeille; M.A. Richard; S. Ingen‐Housz‐Oro; E. Houivet; V.P. Werth; D.F. Murrell; M. Hertl; J. Benichou; P. Joly; ; S. Hofmann; B. Camaioni; B. Didona; L. Fania; R. Della Torre; F. Caux; M. Alexandre; C. Paul; C. Bulai Livideanu; E. Delaporte; A. Dupuy; M. Avenel‐Audran; E. Schmidt; N. Schumacher; M. Bagot; E. Tancrede‐Bohin; J.D. Bouaziz; M. D'Incan; G. Quereux; F. Skowron; M. Beylot‐Barry; M.S. Doutre; C. Bedane; P. Bernard; L. Machet; . Jullien; S. Debarbieux; O. Dereure; C. Hünefeld; S. Schanz; N. Franck; H. Maillard; L. Misery; B. Sassolas; C. Abasq; A.C. Bouyeure; P. Lagoutte; V. Ferranti
• Keywords: Intensity

Two pemphigus severity scores, Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI), have been proposed to provide an objective measure of disease activity. However, the use these scores in clinical practice is limited by absence cut‐off values that allow differentiation between moderate, significant extensive types pemphigus. To calculate defining based on ABSIS PDAI scores. In 31 dermatology departments six countries, consecutive patients with newly diagnosed were assessed for severity, using ABSIS, PDAI, Physician's Global Assessment (PGA) Dermatology Life Quality (DLQI) Cut‐off subgroups calculated 25th 75th percentiles The median PGA DLQI three compared order validate subgroups. Ninety‐six vulgaris (n = 77) or foliaceus 19) included. activity total 27·5 (range 3–84) 34·8 points 0·5–90·5), respectively. respective corresponding first third quartiles 15 45 17 53 ABSIS. thus defined, had distinguishing (P < 0·001), 0·001) 0·03) This study suggests distinguish forms. Identifying should help physicians classify manage