A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis

• DOI: 10.1111/bjd.16994
• Publication Date: 2018-07-10T10:36:43Z
• Authors: L. Hulshof; D.P. Hack; Q.C.J. Hasnoe; B. Dontje; I. Jakasa; C. Riethmüller; W.H.I. McLean; W.M.C. Aalderen; B. van't Land; S. Kezic; A.B. Sprikkelman; M.A. Middelkamp‐Hup
• Keywords: CCL17; CCL22

Atopic dermatitis (AD) affects children of all skin types. Most research has focused on light Studies investigating biomarkers in people with AD dark types are lacking.To explore barrier and immune response stratum corneum (SC) tape strips from different types.Tape were collected lesional nonlesional forearm 53 50 controls. We analysed 28 immunomodulatory mediators, natural moisturizing factors (NMF) corneocyte morphology.Interleukin (IL)-1β, IL-18, C-X-C motif chemokine (CXCL) 8 (CXCL8), C-C ligand (CCL) 22 (CCL22), CCL17, CXCL10 CCL2 significantly higher (P < 0·05) compared skin; the opposite trend was seen for IL-1α. CXCL8, CCL17 showed an association objective SCORing Dermatitis score. NMF levels a gradual decrease healthy to skin. This decreasing pattern observed type II but not VI. Skin VI both than II. Corneocyte morphology skin.Minimally invasive tape-stripping is suitable determination many inflammatory mediators AD. study shows differences between levels, suggesting that some aspects pathophysiological mechanisms may differ versus